35% Fumitrazine OD small test research and development report

1. Difficulties and problems of preparation

High content of oil suspension agent generally exists viscosity, poor pouring, inconvenient to use and so on, 35% Fumitrazine also exists in the following difficulties: 1. Formulation processing viscosity; 2. Shelf life is short, settlement is serious; 3. The original drug decomposition rate is high; 4. Dilution of the stability is poor, the phenomenon of plugging the nozzle is serious.

By adding anti-decomposition agent in the formula, we can effectively control the viscosity of the preparation, the decomposition rate of the original drug and other problems, while the preparation still has good fluidity after 14 days of hot storage.

2. Formulation

3.Detecting the indicators of the preparation

1. Light yellow appearance, good flow at room temperature.

2. Cold storage stability is qualified.

3. 15% oil precipitation in hot storage, good fluidity, small viscosity after shaking the preparation, good pouring.

4. Preparation dilution stability is good, 30 ℃ standard hard water diluted 200 times placed 1h, suspension rate > 98%.

Diluted 100 times with standard hard water, completely transparent, put into the water bath for 24 hours after the dilution did not change significantly.

4.Summary

We also experimented with different content of fumonisin OD, fumonisin OD, nitrazine OD, fumonisin OD and other dosage formulations, all of which can solve the problem of its poor physical stability and high decomposition rate. The formulations have strong versatility and high stability.